DXP reductoisomerase

1-deoxy-D-xylulose 5-phosphate reductoisomerase
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
Identifiers
Symbol DXP_reductoisom
Pfam PF02670
Pfam clan CL0063
InterPro IPR013512
SCOP 1onn
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
Identifiers
Symbol DXP_redisom_C
Pfam PF08436
Pfam clan CL0063
InterPro IPR013644

DXP reductoisomerase or (1-deoxy-d-xylulose 5-phosphate reductoisomerase) is an enzyme that intraconverts 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate.[1]

It is classified under EC 1.1.1.267.

It is part of the non-mevalonate pathway, and it is inhibited by fosmidomycin.

It is normally abbreviated DXR, but it is sometimes named IspC.

This enzyme is responsible for terpenoid biosynthesis in some organisms.[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.

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References

This article incorporates text from the public domain Pfam and InterPro IPR013512

This article incorporates text from the public domain Pfam and InterPro IPR013644